TITLE:    The G-Protein-Receptor database

URL:   http://www.gcrdb.uthscsa.edu/

DATE REVIEWED:  May 8, 2000

DESCRIPTION:  Site is dedicated to G-protein receptor kinases.

This site provides infomation about G-protein coupled receptors: 1. information about GCR database, 2. organization of receptors by families, ligands, species, and evolutionary trees.

This site provides many of its own analysis (sequence aligments, motifs, domains) on GPR, but does not allow you to do your own analysis.

This site links to other databases which contain information about seven transmembrane receptor: (1)  GRAP Mutant Database, (2) GPCR mutant database, (3) Swiss-Model 7TM, (4) Olfactory Receptor Db.

This site provides links to various other sites which allow you to examine the sequence
comparison (BLAST searchs), protein domains and mofits, sequence alignments, sequence
presention tools, etc...

STRENGTHS:

This site provides many links to other programs which allow analysis of your particular 7 transmembrane receptor protein. Thus eliminating the need to go to each sites homepage directly.
 

WEAKNESSES:

This site is not very well organized. One has a difficult time manipulating data and finding the data of interest. Lacks a good search engine.

COMPREHENSIVENESS:

This site is out of date. This site has not been up-dated since August 1999. Seems as if this site is up-dated once a year.
 

TIMELINESS:

Difficult to deterime how up to date this database is because it does not reference the literature.

EASE OF USE:

This site has a nicely layed out home page to access links, but does not have a good search tool
to allow one to find all of the information about their 7 transmembrane receptor of interest.

RESPONSIVENESS:

This site is slow.

SIMILAR OF RELATED SITES:

  Swiss Prot list of receptors
  GPR-Linked Diseases

  GPCRDB
  GRAP Mutant Database
  GPCR mutant database
  Swiss-Model 7TM
  Olfactory Receptor Db

OVER ALL RATING:  1 = BAD    5 = EXCELLENT

I give this site a rating of 2 because it is very difficult to search for all the available information known on the G-protein of interest. It is next to impossible to perform your own analysis on the G-protein of interest.